# AOD-9604 study list

> Simplest Peptides study shelf — The Simplest Peptides reading list: growth-hormone fragments, rat fat synthesis, AOD-9604 mouse metabolism, rabbit cartilage and human tolerability.

**Reading list**

The rat-tissue result introduces the separation between making fat and releasing stored fat. The later experiments carry that distinction into different settings.

## Earlier growth-hormone fragments

Start with the [1993 hGH 177-191 fat-pad study](https://pubmed.ncbi.nlm.nih.gov/8358331/). Then step back to the [enzyme work on hGH 172-191](https://pubmed.ncbi.nlm.nih.gov/6137122/) and forward to [cumulative body-weight gain in obese mice](https://pubmed.ncbi.nlm.nih.gov/7987248/). These studies concern the named growth-hormone fragments; the [AOD-9604 metabolic paper](https://pubmed.ncbi.nlm.nih.gov/11146367/) introduces the later synthetic domain.

## Mouse metabolism; rabbit cartilage

The [beta3-AR knockout experiment](https://pubmed.ncbi.nlm.nih.gov/11713213/) and the [chronic mouse fat-oxidation study](https://pubmed.ncbi.nlm.nih.gov/11673763/) belong beside each other. The [rabbit knee study](https://pubmed.ncbi.nlm.nih.gov/26275694/) addresses cartilage degeneration after administration into the joint.

## Human tolerability reports

The [oral human tolerability report](https://www.jofem.org/index.php/jofem/article/view/157/194) is the direct human comparison discussed on this site. The [later sports-medicine review](https://pubmed.ncbi.nlm.nih.gov/41966639/) provides a wider safety context. The review broadens the safety discussion beyond the earlier trial programme. Full bibliographic details follow.

## References

[1] Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone https://pubmed.ncbi.nlm.nih.gov/8358331/
[2] Metabolic actions of pituitary growth hormone. I. Inhibition of acetyl CoA carboxylase by human growth hormone and a carboxyl terminal part sequence acting through a second messenger https://pubmed.ncbi.nlm.nih.gov/6137122/
[3] Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptide https://pubmed.ncbi.nlm.nih.gov/7987248/
[4] Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone https://pubmed.ncbi.nlm.nih.gov/11146367/
[5] The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice https://pubmed.ncbi.nlm.nih.gov/11713213/
[6] Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment https://pubmed.ncbi.nlm.nih.gov/11673763/
[7] Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model https://pubmed.ncbi.nlm.nih.gov/26275694/
[8] Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans https://www.jofem.org/index.php/jofem/article/view/157/194
[9] Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance https://pubmed.ncbi.nlm.nih.gov/41966639/

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