AOD-9604 study list
The rat-tissue result introduces the separation between making fat and releasing stored fat. The later experiments carry that distinction into different settings.
Earlier growth-hormone fragments
Start with the 1993 hGH 177-191 fat-pad study. Then step back to the enzyme work on hGH 172-191 and forward to cumulative body-weight gain in obese mice. These studies concern the named growth-hormone fragments; the AOD-9604 metabolic paper introduces the later synthetic domain.
Mouse metabolism; rabbit cartilage
The beta3-AR knockout experiment and the chronic mouse fat-oxidation study belong beside each other. The rabbit knee study addresses cartilage degeneration after administration into the joint.
Human tolerability reports
The oral human tolerability report is the direct human comparison discussed on this site. The later sports-medicine review provides a wider safety context. The review broadens the safety discussion beyond the earlier trial programme. Full bibliographic details follow.
- Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone ↗
- Metabolic actions of pituitary growth hormone. I. Inhibition of acetyl CoA carboxylase by human growth hormone and a carboxyl terminal part sequence acting through a second messenger ↗
- Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptide ↗
- Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone ↗
- The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice ↗
- Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment ↗
- Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model ↗
- Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans ↗
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance ↗